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Article

Loss of the TNFα function inhibits Wnt/β-catenin signaling, exacerbates obesity development in adolescent spontaneous obese mice.

Molecular and cellular biochemistry - 1 Jun 2014

Gong Maolei, Liu Chuanguo, Zhang Liang, Zhang Hongbin, Pan Jie

Abstract excerpt

Tumor necrosis factor alpha (TNFα) is an adipokine involved in the regulation of cell differentiation and lipid metabolism, but its specific role has not been clearly understood. We validated a hypothesis that loss of TNFα function would inhibit Wnt/β-catenin signaling and accelerate adipogenesis in adolescent genetic obese mice. Epididymal white adipose tissues (eWAT) from TNFα deficient (TNFα(-/-)), leptin...

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Share to Adipogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24522555
DOI: 10.1007/s11010-014-1987-5
PMCID: PMC4006126

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