Article
Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model.
Hepatology (Baltimore, Md.) - 1 Feb 2013
Aparicio-Vergara Marcela, Hommelberg Pascal P H, Schreurs Marijke, Gruben Nanda, Stienstra Rinke, Shiri-Sverdlov Ronit, Kloosterhuis Niels J, de Bruin Alain, van de Sluis Bart, Koonen Debby P Y, Hofker Marten H
Abstract excerpt
UNLABELLED: Ectodomain shedding of tumor necrosis factor receptor 1 (TNFR1) provides negative feedback to the inflammatory loop induced by TNFα. As the significance of this mechanism in obesity-associated pathologies is unclear, we aimed to unravel how much TNFR1 ectodomain shedding controls the development of nonalcoholic fatty liver disease (NAFLD), as well as its role in the development of insulin resistance....
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