Article
Genomic and allelic expression status of the p73 gene in human neuroblastoma.
Medical and pediatric oncology - 1 Jan 2001
Barrois M, Eychenne M K, Terrier-Lacombe M J, Duarte N, Dubourg C, Douc-Rasy S, Chompret A, Khagad M, Hartmann O, Caput D, Bénard J
Abstract excerpt
BACKGROUND AND PROCEDURE: The p53 gene homologue, p73, is located on the 1p36-3 locus, which is frequently deleted in human neuroblastoma (NB). A survey of 61 NB showed that among 33% of informative cases, p73 loss of heterozygosity (LOH) occurred in 7 of 20 (35%). RESULTS: LOH pattern of vicinal markers suggested that the p73 gene could not be considered as the candidate NB suppressor gene. Moreover, comparative...
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