Article
Overexpression of the wild type p73 gene in breast cancer tissues and cell lines.
Cancer research - 1 Jul 1999
Zaika A I, Kovalev S, Marchenko N D, Moll U M
Abstract excerpt
The p73 gene is a structural and, in overexpression systems, functional p53 homologue. Ectopic p73 expression can activate a broad subset of p53-responsive genes, induce apoptosis, and act as a growth suppressor. Yet, viral oncoproteins that antagonize p53 (adenovirus E1B 55K, SV40 large T, and h...
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