Article
Differential expression and allelotyping of the p73 gene in neuroblastoma.
International journal of oncology - 1 Jan 2000
Liu W, Mai M, Yokomizo A, Qian C, Tindall D J, Smith D I, Thibodeau S N
Abstract excerpt
p73 has recently been identified as a candidate imprinted tumor suppressor gene in neuroblastoma. To determine the possible involvement of this gene in the pathogenesis of neuroblastoma, we analyzed allelic expression, screened for mutations and determined MYCN copy numbers in 31 primary neuroblastoma tumor samples. Interestingly, the gene was biallelically expressed in 50% (4/8) of informative neuroblastomas,...
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