Article
Differential expression of HLA-DQA1 alleles associated with promoter polymorphism.
Immunogenetics - 1 Jan 1997
Morzycka-Wroblewska E, Munshi A, Ostermayer M, Harwood J I, Kagnoff M F
Abstract excerpt
The promoter regions of DQA1 alleles are polymorphic, with some of the nucleotide sequence polymorphisms being located within X and Y motifs essential for the regulation of HLA class II gene transcription. In the present study, we demonstrate that polymorphisms in the promoter regions of three DQA1 alleles influence constitutive and inducible transcription of reporter gene constructs in epithelial, B-, and T-cell...
Topics
- Alleles
- Autoimmune Diseases
- B-Lymphocytes
- Base Sequence
- Cell Line
- DNA
- Gene Expression
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Humans
- Lymphocyte Activation
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Promoter Regions, Genetic
- T-Lymphocytes
- Transcription, Genetic
- Tumor Cells, Cultured