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Article

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype.

Pharmacogenetics - 1 Oct 1998

Powell H, Kitteringham N R, Pirmohamed M, Smith D A, Park B K

Abstract excerpt

Cytochrome P4502E1 (CYP2E1) is constitutively expressed in human liver and is responsible for the metabolic bioactivation of a wide variety of xenobiotics, including a number of protoxins and procarcinogens. CYP2E1 expression is regulated at several levels including pre-transcriptional, transcrip...

Topics

Adult
Aged
Chlorzoxazone
Cytochrome P-450 CYP2E1
Female
Genotype
Humans
Hydroxylation
Liver
Male
Middle Aged
Nitrophenols
Phenotype

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Polymorphism, Restriction Fragment Length

RNA, Messenger

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Identifiers

PMID: 9825833
DOI: 10.1097/00008571-199810000-00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9825833-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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