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Article

Functional PstI/RsaI polymorphisms in the CYP2E1 gene among south Indian populations.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Lakkakula Saikrishna, Maram Rajasekhar, Munirajan Arasambattu Kannan, Pathapati Ram Mohan, Visveswara Subrahmanyam Bhattaram, Lakkakula Bhaskar Vks

Abstract excerpt

Human cytochrome P4502E1 (CYP2E1) is a well-conserved xenobiotic-metabolizing enzyme expressed in liver, kidney, nasal mucosa, brain, lung, and other tissues. CYP2E1 is inducible by ethanol, acetone, and other low-molecular weight substrates and may mediate development of chemically-mediated cancers. CYP2E1 polymorphisms alter the transcriptional activity of the gene. This study was conducted in order to...

Topics

5' Flanking Region
Cytochrome P-450 CYP2E1
Gene Frequency
Genotype
Humans
India
Introns
Polymorphism, Single Nucleotide
White People

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PMID: 23534720

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