Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.

doi:10.1093/oxfordjournals.jbchem.a124526

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.

Journal of biochemistry - 1 Aug 1994

Watanabe J, Hayashi S, Kawajiri K

Abstract excerpt

The effects of two genetically associated polymorphisms [c1 allele: PstI -, RsaI +; c2 allele: PstI +, RsaI -] in the 5'-flanking region on the regulation and expression of the human CYP2E1 gene were investigated. DNase I footprinting and CAT activity analyses using various deletion mutants const...

Topics

Alleles
Base Sequence
Chloramphenicol O-Acetyltransferase
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Deoxyribonucleases, Type II Site-Specific
Gene Expression
Gene Expression Regulation
Genotype
Humans
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oxidoreductases, N-Demethylating

Plasmids

Polymerase Chain Reaction

Polymorphism, Genetic

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 7529759
DOI: 10.1093/oxfordjournals.jbchem.a124526

Genes

CAT
GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7529759-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.PMID 7529759Read ↗

RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.Semantic proximity Read ↗

Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.Semantic proximity Read ↗

The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.Semantic proximity Read ↗

CYP2E1 PstI/RsaI polymorphism and interaction with alcohol consumption in hepatocellular carcinoma susceptibility: evidence from 1,661 cases and 2,317 controls.Semantic proximity Read ↗

Functional PstI/RsaI polymorphisms in the CYP2E1 gene among south Indian populations.Semantic proximity Read ↗

CYP2E1 RsaI/PstI polymorphism and liver cancer risk among east Asians: a HuGE review and meta-analysis.Semantic proximity Read ↗

CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.Semantic proximity Read ↗

An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.Semantic proximity Read ↗

Genetic polymorphism of cytochrome P450 2E1 in the Turkish population.Semantic proximity Read ↗

Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer.Semantic proximity Read ↗

Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.Semantic proximity Read ↗

Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.