Article
Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects.
Pharmacogenetics - 1 Oct 1995
Lucas D, Ménez C, Girre C, Berthou F, Bodénez P, Joannet I, Hispard E, Bardou L G, Ménez J F
Abstract excerpt
Susceptibility to cancer or ethanol-related liver diseases may be associated with a large variability in cytochrome P450 2E1 activity. This variability may be of genetic origin or reflect environmental factors. To test the role of genetics, the phenotype and genotype of this enzyme were determine...
Topics
- Adult
- Alcoholism
- Chlorzoxazone
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genotype
- Humans
- Male
- Oxidoreductases, N-Demethylating
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Reference Values
- Smoking
- White People