Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo.

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Article

Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo.

Cancer research - 15 Nov 1998

Crawford H C, Matrisian L M, Liaw L

Abstract excerpt

Secreted phosphoprotein 1 (spp1), the gene encoding osteopontin (OPN), is expressed in many human carcinomas, although its in vivo functions remain unclear. To delineate the role of OPN during tumor progression, we have subjected OPN null mutant mice to repeated applications of a mutagen/carcinog...

Topics

Animals
Carcinogens
Carcinoma
Carcinoma, Squamous Cell
Cell Count
Cell Division
Disease Progression
Female
Male
Methylnitronitrosoguanidine
Mice
Neoplasm Proteins
Osteopontin
Papilloma
Phenotype
Sialoglycoproteins
Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 9823334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9823334-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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