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Article

Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo.

Cancer research - 15 Nov 1998

Crawford H C, Matrisian L M, Liaw L

Abstract excerpt

Secreted phosphoprotein 1 (spp1), the gene encoding osteopontin (OPN), is expressed in many human carcinomas, although its in vivo functions remain unclear. To delineate the role of OPN during tumor progression, we have subjected OPN null mutant mice to repeated applications of a mutagen/carcinogen to induce cutaneous squamous cell carcinoma. OPN null animals exhibited accelerated tumor growth and progression and...

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PMID: 9823334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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