Article
Osteopontin drives KRAS-mutant lung adenocarcinoma.
Carcinogenesis - 12 Aug 2020
Giopanou Ioanna, Kanellakis Nikolaos I, Giannou Anastasios D, Lilis Ioannis, Marazioti Antonia, Spella Magda, Papaleonidopoulos Vassilios, Simoes Davina C M, Zazara Dimitra E, Agalioti Theodora, Moschos Charalampos, Magkouta Sophia, Kalomenidis Ioannis, Panoutsakopoulou Vily, Lamort Anne-Sophie, Stathopoulos Georgios T, Psallidas Ioannis
Abstract excerpt
Increased expression of osteopontin (secreted phosphoprotein 1, SPP1) is associated with aggressive human lung adenocarcinoma (LADC), but its function remains unknown. Our aim was to determine the role of SPP1 in smoking-induced LADC. We combined mouse models of tobacco carcinogen-induced LADC, of deficiency of endogenous Spp1 alleles, and of adoptive pulmonary macrophage reconstitution to map the expression of...
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