Article
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway.
Molecular cancer research : MCR - 1 Aug 2011
Luo Xianmin, Ruhland Megan K, Pazolli Ermira, Lind Anne C, Stewart Sheila A
Abstract excerpt
Alterations in the microenvironment collaborate with cell autonomous mutations during the transformation process. Indeed, cancer-associated fibroblasts and senescent fibroblasts stimulate tumorigenesis in xenograft models. Because senescent fibroblasts accumulate with age, these findings suggest that they contribute to age-related increases in tumorigenesis. Previously we showed that senescence-associated...
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