TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.

doi:10.1016/s0960-9822(07)00533-7

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Article

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.

Current biology : CB - 19 Nov 1998

Oft M, Heider K H, Beug H

Abstract excerpt

BACKGROUND: Invasive growth of epithelial tumor cells, a major cause of death from cancer in humans, involves loss of epithelial polarity and dedifferentiation. Transforming growth factor beta (TGFbeta) is regarded as a major tumor suppressor during early tumor development because it inhibits cel...

Topics

Animals
Cell Cycle
Colonic Neoplasms
Epithelial Cells
Humans
Mesoderm
Mice
Mutation
Neoplasm Invasiveness
Neoplasm Metastasis
Receptors, Transforming Growth Factor beta
Signal Transduction
Transforming Growth Factor beta
Tumor Cells, Cultured

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