Article
TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis.
Current biology : CB - 19 Nov 1998
Oft M, Heider K H, Beug H
Abstract excerpt
BACKGROUND: Invasive growth of epithelial tumor cells, a major cause of death from cancer in humans, involves loss of epithelial polarity and dedifferentiation. Transforming growth factor beta (TGFbeta) is regarded as a major tumor suppressor during early tumor development because it inhibits cell-cycle progression and tumor growth. Many dedifferentiated, late-stage tumors are resistant to growth inhibition by...
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