Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGFβ-SMAD2/3 signaling inhibits IRF2 to drive metastasis in KRAS-mutant colorectal cancer.

Cancer letters - 10 Jul 2026

Shu Feng, Zhang Tao, Chen Xiaoning, Lu Guohao, Guo Shi, Zhang Yaxin, Huang Chengmei, Liao Wenting, Alan Wang Y

Abstract excerpt

KRAS-mutant colorectal cancer (CRC) exhibits an aggressive metastatic phenotype, largely driven by TGFβ-induced epithelial-mesenchymal transition (EMT). However, the downstream effectors mediating TGFβ-driven metastasis in this context remain incompletely defined. This study identifies interferon regulatory factor 2 (IRF2) as a key metastasis suppressor and direct transcriptional repression target of TGFβ-SMAD2/3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins p21(ras)

Share to Smad2 Protein

Share to Smad3 Protein

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 41985874
DOI: 10.1016/j.canlet.2026.218507

Genes

SMAD2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGFβ-SMAD2/3 signaling inhibits IRF2 to drive metastasis in KRAS-mutant colorectal cancer.PMID 41985874Read ↗

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.Semantic proximity Read ↗

The IRF family can influence tumor immunity and the prognosis of patients with colorectal cancerSemantic proximity Read ↗

Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHCSemantic proximity Read ↗

IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1Semantic proximity Read ↗

Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC.Semantic proximity Read ↗

TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell TransitionSemantic proximity Read ↗

SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasisSemantic proximity Read ↗

STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancerSemantic proximity Read ↗

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtypeSemantic proximity Read ↗

CSF3 contributes to the invasive and metastatic phenotypes and associates with poor prognosis in patients with colorectal cancer via NF-κB signaling pathwaySemantic proximity Read ↗

Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent mannerSemantic proximity Read ↗

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.