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Article

De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.

Journal of medicinal chemistry - 19 Nov 1998

Liao S, Alfaro-Lopez J, Shenderovich M D, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan K A, Porreca F, Yamamura H I, Hruby V J

Abstract excerpt

On the basis of the structure-activity relationships of delta-opioid-selective peptide ligands and on a model of the proposed bioactive conformation for a potent and selective, conformationally constrained delta-opioid peptide ligand [(2S, 3R)-TMT1]DPDPE, a series of small organic peptide mimetic compounds targeted for the delta-opioid receptor have been designed, synthesized, and evaluated in radiolabeled ligand...

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Identifiers

PMID: 9822547
DOI: 10.1021/jm980374r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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