Article
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.
Journal of medicinal chemistry - 19 Nov 1998
Liao S, Alfaro-Lopez J, Shenderovich M D, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan K A, Porreca F, Yamamura H I, Hruby V J
Abstract excerpt
On the basis of the structure-activity relationships of delta-opioid-selective peptide ligands and on a model of the proposed bioactive conformation for a potent and selective, conformationally constrained delta-opioid peptide ligand [(2S, 3R)-TMT1]DPDPE, a series of small organic peptide mimetic...
Topics
- Animals
- Benzhydryl Compounds
- Brain
- Drug Design
- Guinea Pigs
- Humans
- Ileum
- In Vitro Techniques
- Ligands
- Male
- Mice
- Mice, Inbred ICR
- Molecular Mimicry
- Muscle Contraction
- Muscle, Smooth