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Article

Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study.

Journal of neurochemistry - 1 Jan 1997

Mansour A, Taylor L P, Fine J L, Thompson R C, Hoversten M T, Mosberg H I, Watson S J, Akil H

Abstract excerpt

Structural elements of the rat mu-opioid receptor important in ligand receptor binding and selectivity were examined using a site-directed mutagenesis approach. Five single amino acid mutations were made, three that altered conserved residues in the mu, delta, and kappa receptors (Asn150 to Ala,...

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Identifiers

PMID: 8978745
DOI: 10.1046/j.1471-4159.1997.68010344.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8978745-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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