Article
Molecular basis for the subtype discrimination of the estrogen receptor-beta-selective ligand, diarylpropionitrile.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2003
Sun Jun, Baudry Jerome, Katzenellenbogen John A, Katzenellenbogen Benita S
Abstract excerpt
Although the two subtypes of the human estrogen receptor (ER), ERalpha and ERbeta, share only 56% amino acid sequence identity in their ligand binding domain (LBD), the residues that surround the ligand are nearly identical; nevertheless, subtype-selective ligands are known. To understand the molecular basis by which diarylpropionitrile (DPN), an ERbeta-selective ligand, is able to discriminate between the two...
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