Article
Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.
Journal of medicinal chemistry - 28 Aug 2014
Ananthan Subramaniam, Saini Surendra K, Zhou Guangyan, Hobrath Judith V, Padmalayam Indira, Zhai Ling, Bostwick J Robert, Antonio Tamara, Reith Maarten E A, McDowell Shea, Cho Eunie, McAleer Leah, Taylor Michelle, Luedtke Robert R
Abstract excerpt
Antagonist and partial agonist modulators of the dopamine D3 receptor (D3R) have emerged as promising therapeutics for the treatment of substance abuse and neuropsychiatric disorders. However, development of druglike lead compounds with selectivity for the D3 receptor has been challenging because of the high sequence homology between the D3R and the dopamine D2 receptor (D2R). In this effort, we synthesized a...
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