Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemotype-selective modes of action of κ-opioid receptor agonists.

The Journal of biological chemistry - 29 Nov 2013

Vardy Eyal, Mosier Philip D, Frankowski Kevin J, Wu Huixian, Katritch Vsevolod, Westkaemper Richard B, Aubé Jeffrey, Stevens Raymond C, Roth Bryan L

Abstract excerpt

The crystal structures of opioid receptors provide a novel platform for inquiry into opioid receptor function. The molecular determinants for activation of the κ-opioid receptor (KOR) were studied using a combination of agonist docking, functional assays, and site-directed mutagenesis. Eighteen positions in the putative agonist binding site of KOR were selected and evaluated for their effects on receptor binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Ligands

Share to Molecular Docking Simulation

Share to Mutagenesis, Site-Directed

Share to Receptors, Opioid, kappa

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 24121503
DOI: 10.1074/jbc.M113.515668
PMCID: PMC3843062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemotype-selective modes of action of κ-opioid receptor agonists.PMID 24121503Read ↗

Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor.Semantic proximity Read ↗

Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.Semantic proximity Read ↗

Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches.Semantic proximity Read ↗

Structure-Guided Design of Partial Agonists at an Opioid ReceptorSemantic proximity Read ↗

Mutational analysis of the structure and function of opioid receptors.Semantic proximity Read ↗

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).Semantic proximity Read ↗

Residues W320 and Y328 within the binding site of the μ-opioid receptor influence opiate ligand bias.Semantic proximity Read ↗

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.Semantic proximity Read ↗

Proton-gating of opioid receptors and isoform functionalitySemantic proximity Read ↗

Opioid receptors.Semantic proximity Read ↗

New vistas in opioid control of pain.Semantic proximity Read ↗

Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.