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Article

Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.

Molecular pharmacology - 1 Dec 1997

Spivak C E, Beglan C L, Seidleck B K, Hirshbein L D, Blaschak C J, Uhl G R, Surratt C K

Abstract excerpt

The mu-opioid receptor is the principal site of action in the brain by which morphine, other opiate drugs of abuse, and endogenous opioid peptides effect analgesia and alter mood. A member of the seven-transmembrane domain (TM) G protein-coupled receptor (GPCR) superfamily, the mu-opioid receptor...

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Identifiers

PMID: 9415708
DOI: 10.1124/mol.52.6.983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9415708-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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