Article
Genomic instability and the role of p53 mutations in cancer cells.
Current opinion in oncology - 1 Jan 1995
Smith M L, Fornace A J
Abstract excerpt
The p53 tumor-suppressor gene encodes a cell-cycle checkpoint protein that functions in the G1 phase of the cell cycle. When DNA damage is incurred, p53 transactivates a number of downstream genes whose products, with diverse biologic activities, each make a contribution to the cellular response to DNA damage. One major p53-mediated stress response is the G1 cell-cycle arrest, or delay, which probably allows the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.