Article
Genomic instability and the role of p53 mutations in cancer cells.
Current opinion in oncology - 1 Jan 1995
Smith M L, Fornace A J
Abstract excerpt
The p53 tumor-suppressor gene encodes a cell-cycle checkpoint protein that functions in the G1 phase of the cell cycle. When DNA damage is incurred, p53 transactivates a number of downstream genes whose products, with diverse biologic activities, each make a contribution to the cellular response...
Topics
- Animals
- Genes, p53
- Humans
- Mutation
- Neoplasms
- Neoplasms, Experimental