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p53 Promotes Cell Survival due to the Reversibility of Its Cell-Cycle Checkpoints

26 Aug 2014

Abstract excerpt

UNLABELLED: The tumor suppressor p53 (TP53) has a well-studied role in triggering cell-cycle checkpoint in response to DNA damage. Previous studies have suggested that functional p53 enhances chemosensitivity. In contrast, data are presented to show that p53 can be required for cell survival following DNA damage due to activation of reversible cell-cycle checkpoints. The cellular outcome to DNA damage is...

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Identifiers

PMID: 25158956
DOI: 10.1158/1541-7786.mcr-14-0177

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