The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators

Abstract excerpt

Transcriptional control of gene expression contributes to the regulation of diverse cellular processes including cell cycle progression and the cellular response to DNA damage. Global gene expression profiling was performed using p53-deficient human cells to identify genes with G(2)/M-specific and DNA damage-responsive expression. Numerous cell cycle-regulated genes were identified, but surprisingly the analysis...

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