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Article

Functionality of two new polymorphisms in the human renin gene enhancer region.

Journal of hypertension - 1 Dec 2002

Fuchs Sébastien, Philippe Josette, Germain Stephane, Mathieu Flavie, Jeunemaitre Xavier, Corvol Pierre, Pinet Florence

Abstract excerpt

BACKGROUND: The production of renin, which catalyses the rate-limiting step of the renin-angiotensin system, is strongly stimulated by a 225 bp enhancer element in the distal region of the promoter of the human gene (-5777 to -5552). OBJECTIVE: To demonstrate the major role played by this enhancer in decoy experiments, to identify variants in this region, and to determine their effects on renin gene...

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Identifiers

PMID: 12473863
DOI: 10.1097/00004872-200212000-00018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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