Article
Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1996
Elbendary A A, Cirisano F D, Evans A C, Davis P L, Iglehart J D, Marks J R, Berchuck A
Abstract excerpt
In many cell types, p53-mediated growth inhibition is dependent on induction of p21, which is an inhibitor of cyclin-dependent kinases that are required for cell cycle progression. Failure of mutant p53 proteins to transactivate p21 may lead to uncontrolled proliferation. Because many ovarian cancers have mutations in the p53 gene, we examined p21 levels in normal and malignant ovarian epithelial cells to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.