Article
Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1996
Elbendary A A, Cirisano F D, Evans A C, Davis P L, Iglehart J D, Marks J R, Berchuck A
Abstract excerpt
In many cell types, p53-mediated growth inhibition is dependent on induction of p21, which is an inhibitor of cyclin-dependent kinases that are required for cell cycle progression. Failure of mutant p53 proteins to transactivate p21 may lead to uncontrolled proliferation. Because many ovarian can...
Topics
- Blotting, Northern
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Epithelial Cells
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Mutation
- Ovary
- RNA, Messenger
- Tumor Cells, Cultured