Article
p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP.
Journal of Korean medical science - 1 Oct 1998
Park Y E, Choi K C, Choi Y H
Abstract excerpt
p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a central role in tumor suppression. In this study we investigated p21 protein expression and mutation in gastric adenocarcinoma. A t...
Topics
- Adenocarcinoma
- Adult
- Aged
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Female
- Gene Expression
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA
- Staining and Labeling
- Stomach Neoplasms