Article
Expression of the p53 induced tumor suppressor p21waf1/cip1 in ovarian carcinomas: correlation with p53 and Ki-67 immunohistochemistry.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Apr 1997
Werness B A, Jobe J S, DiCioccio R A, Piver M S
Abstract excerpt
Mutations of the p53 gene are the most common genetic alteration in malignant human tumors, including ovarian carcinomas of surface epithelial origin. A cyclin-dependent kinase inhibitor, p21waf1/cip1, is thought to be an important mediator of p53-induced cell cycle arrest. Although numerous stud...
Topics
- Cell Differentiation
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Female
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Ki-67 Antigen
- Mutation
