Article
Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.
Oncogene - 1 Aug 1994
Li Y, Jenkins C W, Nichols M A, Xiong Y
Abstract excerpt
In normal human fibroblast cells, the primary cell cycle regulators, the cyclin-dependent kinases (CDKs), exist predominantly in multiple quaternary complexes, each consisting of a CDK, a cyclin, proliferating cell nuclear antigen (PCNA) and p21. p21 encodes a universal inhibitor of cyclin-depend...
Topics
- CDC2-CDC28 Kinases
- Cell Cycle
- Cells, Cultured
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- Gene Expression Regulation
- Genes, p53
- Humans
- Mutation
- Nuclear Proteins
- Proliferating Cell Nuclear Antigen
- Protein Kinase Inhibitors
- Protein Serine-Threonine Kinases
- Proteins
- Proto-Oncogene Proteins