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Article

Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.

Oncogene - 1 Aug 1994

Li Y, Jenkins C W, Nichols M A, Xiong Y

Abstract excerpt

In normal human fibroblast cells, the primary cell cycle regulators, the cyclin-dependent kinases (CDKs), exist predominantly in multiple quaternary complexes, each consisting of a CDK, a cyclin, proliferating cell nuclear antigen (PCNA) and p21. p21 encodes a universal inhibitor of cyclin-dependent kinases. Here we show that the level of p21 mRNA and the interaction of p21 protein with cyclin-CDK enzymes are...

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Source

Identifiers

PMID: 7913544

Genes

PCNA
CDK4
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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