Article
Anti-p53 antibodies in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1996
Trivers G E, De Benedetti V M, Cawley H L, Caron G, Harrington A M, Bennett W P, Jett J R, Colby T V, Tazelaar H, Pairolero P, Miller R D, Harris C C
Abstract excerpt
Serum anti-p53 antibodies (p53-Abs) may be surrogate markers for both p53 alterations and preclinical cancer. Ancillary to a prospective trial to abate progressive development of clinical stages of chronic obstructive pulmonary disease, we conducted a retrospective, nested case-control study. Twe...
Topics
- Aged
- Aged, 80 and over
- Antibodies
- Antibodies, Neoplasm
- Case-Control Studies
- DNA Mutational Analysis
- Female
- Humans
- Immunoblotting
- Immunoenzyme Techniques
- Immunohistochemistry
- Lung Diseases, Obstructive
- Male