p53 antibodies in the sera of lung cancer patients: comparison with p53 mutation in the tumour tissue.

doi:10.1002/ijc.2910640306

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Article

p53 antibodies in the sera of lung cancer patients: comparison with p53 mutation in the tumour tissue.

International journal of cancer - 22 Jun 1995

Wild C P, Ridanpää M, Anttila S, Lubin R, Soussi T, Husgafvel-Pursiainen K, Vainio H

Abstract excerpt

This study examined the sensitivity and specificity of serum auto-antibodies to p53 protein as a non-invasive marker of p53 genetic alterations or protein accumulation in lung cancer cases. A sensitive ELISA to detect serum p53 antibodies was developed and used to examine sera from 186 patients u...

Topics

Autoantibodies
Enzyme-Linked Immunosorbent Assay
Genes, p53
Humans
Lung Neoplasms
Mutation
Tumor Suppressor Protein p53

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