Article
Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis.
Gastroenterology - 1 Jul 1998
Cawley H M, Meltzer S J, De Benedetti V M, Hollstein M C, Muehlbauer K R, Liang L, Bennett W P, Souza R F, Greenwald B D, Cottrell J, Salabes A, Bartsch H, Trivers G E
Abstract excerpt
BACKGROUND & AIMS: We previously discovered anti-p53 antibodies predating a cancer diagnosis in subjects at increased risk for liver, lung, breast, and prostate cancer. Recently, we reported a significant correlation (P < 0.017) between p53 antibodies and p53 mutations in patients with late-stage...
Topics
- Adenocarcinoma
- Adult
- Aged
- Antibodies
- Barrett Esophagus
- Carcinoma, Squamous Cell
- DNA
- Esophageal Neoplasms
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Tumor Suppressor Protein p53