Article
Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis.
Gastroenterology - 1 Jul 1998
Cawley H M, Meltzer S J, De Benedetti V M, Hollstein M C, Muehlbauer K R, Liang L, Bennett W P, Souza R F, Greenwald B D, Cottrell J, Salabes A, Bartsch H, Trivers G E
Abstract excerpt
BACKGROUND & AIMS: We previously discovered anti-p53 antibodies predating a cancer diagnosis in subjects at increased risk for liver, lung, breast, and prostate cancer. Recently, we reported a significant correlation (P < 0.017) between p53 antibodies and p53 mutations in patients with late-stage esophageal carcinoma. Because others have reported p53 mutations and overexpression of p53 protein in Barrett's...
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