Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.

Cancer research - 1 Aug 1992

Winter S F, Minna J D, Johnson B E, Takahashi T, Gazdar A F, Carbone D P

Abstract excerpt

Using immunoblotting techniques we studied the sera from small cell lung cancer and non-small cell lung cancer patients for antibodies directed against p53. We have also characterized the majority of these patients' tumors for p53 mutations. In the sera of 13% of the patients (4 of 40 small cell lung cancer and 2 of 6 non-small cell lung cancer) we found antibodies specific for the p53 tumor suppressor gene...

Topics

Adenocarcinoma
Adenocarcinoma, Bronchiolo-Alveolar
Adult
Aged
Antibodies, Anti-Idiotypic
Antibodies, Neoplasm
Carcinoma, Small Cell
Carcinoma, Squamous Cell
Cell Line
Female
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Neoplasm Staging

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1322237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1322237-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.PMID 1322237Read ↗

p53 antibodies in the sera of lung cancer patients: comparison with p53 mutation in the tumour tissue.Semantic proximity Read ↗

Serum p53 antibodies as early markers of lung cancer.Semantic proximity Read ↗

Anti-p53 antibodies in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer.Semantic proximity Read ↗

Strong association between P53 protein accumulation, serum antibodies and gene mutation in non-small cell lung cancer.Semantic proximity Read ↗

Detection of serum p53 protein in lung cancer patients.Semantic proximity Read ↗

Analysis of the anti-p53 antibody response in cancer patients.Semantic proximity Read ↗

Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.Semantic proximity Read ↗

Analysis of p53 antibody response in patients with squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Immunohistochemical study of p53 in human lung carcinomas.Semantic proximity Read ↗

The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the alpha-fetoprotein status.Semantic proximity Read ↗

p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival.Semantic proximity Read ↗

Detection of p53 mutations in sputum smears precedes diagnosis of non-small cell lung carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.