Article
Strong association between P53 protein accumulation, serum antibodies and gene mutation in non-small cell lung cancer.
Folia histochemica et cytobiologica - 1 Jan 2001
Niklinska W, Burzykowski T, Laudanski J, Chyczewska E, Chyczewski L, Niklinski J
Abstract excerpt
DNA sequencing is the gold-standard method, but it is not feasible on a routine clinical basis. Immunohistochemistry is the most widely used method for assessing P53 alterations in human cancers. It can be performed during routine analysis, but some mutations may not lead to P53 protein accumulation, or P53 overexpression may be detected in the absence of mutations of the P53 gene. Recent studies have...
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