Article
Detection of p53 mutations in sputum smears precedes diagnosis of non-small cell lung carcinoma.
Anticancer research - 1 Jan 2000
Chen J T, Ho W L, Cheng Y W, Lee H
Abstract excerpt
Little progress has been made in reducing lung cancer mortality by applying conventional methods to early diagnosis and screening. Recent advances in molecular oncology, however, have provided tools which may be of use in this area. p53 gene mutation is the most common gene alteration in the development of lung cancer. Conventional cytologic analysis of sputum is an insensitive test for the diagnosis of lung...
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