Loss of P16INK4 expression is frequent in high grade gliomas.

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Article

Loss of P16INK4 expression is frequent in high grade gliomas.

Cancer research - 1 May 1995

Nishikawa R, Furnari F B, Lin H, Arap W, Berger M S, Cavenee W K, Su Huang H J

Abstract excerpt

P16INK4 is a cell cycle regulator that specifically binds to and inactivates cyclin-dependent kinase 4 (CDK4). Its encoding gene (p16/CDKN2) maps to chromosome 9p21, a region that undergoes frequent loss of heterozygosity in a variety of human tumors. We have analyzed the p16/CDKN2 gene and its e...

Topics

Astrocytoma
Base Sequence
Blotting, Western
Brain Neoplasms
Carrier Proteins
Cyclin-Dependent Kinase Inhibitor p16
Disease Progression
Gene Deletion
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glioblastoma

Humans

Molecular Sequence Data

Mutation

Protein Kinase Inhibitors

RNA, Messenger

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7728764

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7728764-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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