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Article

The monomeric guanosine triphosphatase rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cells.

The Journal of experimental medicine - 16 Nov 1998

Lazzarino D A, Blier P, Mellman I

Abstract excerpt

Each member of the rab guanosine triphosphatase protein family assists in the regulation of a specific step within the biosynthetic or endocytic pathways. We have found that the early endosome-associated rab4 protein controls a step critical for receptor-mediated antigen processing in a murine A20 B cell line. Expression of the dominant negative rab4N121I mutant dramatically inhibited the processing and...

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Identifiers

PMID: 9815254
DOI: 10.1084/jem.188.10.1769
PMCID: PMC2212406

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