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Article

Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domain.

The Journal of biological chemistry - 27 Feb 2015

Vaughan Andrew T, Chan Claude H T, Klein Christian, Glennie Martin J, Beers Stephen A, Cragg Mark S

Abstract excerpt

Type I anti-CD20 mAb such as rituximab and ofatumumab engage with the inhibitory FcγR, FcγRIIb on the surface of B cells, resulting in immunoreceptor tyrosine-based inhibitory motif (ITIM) phosphorylation. Internalization of the CD20·mAb·FcγRIIb complex follows, the rate of which correlates with FcγRIIb expression. In contrast, although type II anti-CD20 mAb such as tositumomab and obinutuzumab also interact with...

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Topics

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Share to Antibodies, Monoclonal, Murine-Derived
Share to Antigens, CD20

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biotinylation

Share to Blotting, Western

Share to Endocytosis

Share to Microscopy, Confocal

Share to Receptors, IgG

Share to Rituximab

Source

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Identifiers

PMID: 25568316
DOI: 10.1074/jbc.M114.593806
PMCID: PMC4342459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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