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Article

COOH terminus of membrane IgM is essential for an antigen-specific induction of some but not all early activation events in mature B cells.

The Journal of experimental medicine - 1 Nov 1991

Parikh V S, Nakai C, Yokota S J, Bankert R B, Tucker P W

Abstract excerpt

Transfectants of mature B cell lines that bind phosphorylcholine were made in order to understand the role of the COOH terminus of the mu chain of membrane IgM (mIgM) in generation of antigen-specific signals. A chimeric receptor (I-A alpha tail) was constructed by replacing 40 amino acids from the mu COOH terminus with that of major histocompatibility complex class II I-A alpha chain. The effect of wild-type and...

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Identifiers

PMID: 1940791
DOI: 10.1084/jem.174.5.1103
PMCID: PMC2119015

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Source receipt: pubmed, retrieved 7 Sept 2026.

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