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Article

COOH terminus of membrane IgM is essential for an antigen-specific induction of some but not all early activation events in mature B cells.

The Journal of experimental medicine - 1 Nov 1991

Parikh V S, Nakai C, Yokota S J, Bankert R B, Tucker P W

Abstract excerpt

Transfectants of mature B cell lines that bind phosphorylcholine were made in order to understand the role of the COOH terminus of the mu chain of membrane IgM (mIgM) in generation of antigen-specific signals. A chimeric receptor (I-A alpha tail) was constructed by replacing 40 amino acids from the mu COOH terminus with that of major histocompatibility complex class II I-A alpha chain. The effect of wild-type and...

Topics

Amino Acid Sequence
Animals
Antigens
B-Lymphocytes
Calcium
Cell Line
Endocytosis
Histocompatibility Antigens Class II
Immunoglobulin M
Lymphocyte Activation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Proto-Oncogenes

RNA, Messenger

Receptors, Antigen, B-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 1940791
DOI: 10.1084/jem.174.5.1103
PMCID: PMC2119015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1940791-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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