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Article

EGF domain swap converts a drosophila EGF receptor activator into an inhibitor.

Genes & development - 1 Apr 1998

Schnepp B, Donaldson T, Grumbling G, Ostrowski S, Schweitzer R, Shilo B Z, Simcox A

Abstract excerpt

In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which the EGF domain of Vn was swapped with the EGF domain from each factor. The modified Vn proteins behaved both in vitro and...

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Identifiers

PMID: 9531530
DOI: 10.1101/gad.12.7.908
PMCID: PMC316677

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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