Article
EGF domain swap converts a drosophila EGF receptor activator into an inhibitor.
Genes & development - 1 Apr 1998
Schnepp B, Donaldson T, Grumbling G, Ostrowski S, Schweitzer R, Shilo B Z, Simcox A
Abstract excerpt
In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which th...
Topics
- Amino Acid Sequence
- Animals
- Drosophila
- Drosophila Proteins
- Epidermal Growth Factor
- ErbB Receptors
- Eye
- Eye Proteins
- Genetic Engineering
- Insect Proteins
- Membrane Proteins
- Molecular Sequence Data
- Nerve Tissue Proteins
- Neuregulins
- Phenotype
- Recombinant Fusion Proteins
- Sequence Alignment
- Sequence Homology, Amino Acid