Article
Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback.
Development (Cambridge, England) - 1 Sept 2009
Boisclair Lachance Jean-François, Fregoso Lomas Mariana, Eleiche Aliaa, Bouchard Kerr Phoenix, Nilson Laura A
Abstract excerpt
The pattern of the Drosophila eggshell is determined by the establishment of a complex and stereotyped pattern of cell fates in the follicular epithelium of the ovary. Localized activation of the Epidermal growth factor receptor (Egfr) is essential for this patterning. Modulation of Egfr pathway activity in time and space determines distinct fates at their appropriate locations, but the details of how Egfr...
Topics
- Animals
- Animals, Genetically Modified
- Autocrine Communication
- Biomarkers
- Body Patterning
- Cell Lineage
- Drosophila Proteins
- Drosophila melanogaster
- Epidermal Growth Factor
- ErbB Receptors
- Eye Proteins
- Female
- Homeodomain Proteins
- Male