Article
Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.
Gene therapy - 1 Jan 1994
Liu J, Woffendin C, Yang Z Y, Nabel G J
Abstract excerpt
Infection by the human immunodeficiency virus (HIV) has remained refractory to treatment, and molecular genetic interventions have been developed for the treatment of the acquired immunodeficiency syndrome (AIDS). Previous studies have focused on the development of gene products which inhibit productive HIV replication, including transdominant proteins, RNA decoys and ribozymes. In this report, we show that...
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