Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.

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Article

Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.

Gene therapy - 1 Jan 1994

Liu J, Woffendin C, Yang Z Y, Nabel G J

Abstract excerpt

Infection by the human immunodeficiency virus (HIV) has remained refractory to treatment, and molecular genetic interventions have been developed for the treatment of the acquired immunodeficiency syndrome (AIDS). Previous studies have focused on the development of gene products which inhibit pro...

Topics

Acquired Immunodeficiency Syndrome
Cells, Cultured
Enhancer Elements, Genetic
Gene Expression Regulation, Viral
Genes, Dominant
Genes, rev
Genes, tat
Genetic Therapy
Genetic Vectors
HIV-1
Humans
Mutation
Plasmids
T-Lymphocytes
Transfection
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 7584057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7584057-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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