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Article

Silencing of human immunodeficiency virus long terminal repeat expression by an adenovirus E1a mutant.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Ventura A M, Arens M Q, Srinivasan A, Chinnadurai G

Abstract excerpt

Gene expression from the human immunodeficiency virus (HIV) long terminal repeat (LTR) is strongly stimulated by the viral tat gene. The HIV LTR is also activated by several physical and chemical agents and heterologous viral genes, including adenovirus E1a. As E1a has separable transcriptional activation and repression functions, we examined the negative regulatory effects of E1a on the expression of the HIV LTR...

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Identifiers

PMID: 2137611
DOI: 10.1073/pnas.87.4.1310
PMCID: PMC53464

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