Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the -427T/C apolipoprotein E promoter polymorphism in the pathogenesis of Alzheimer's disease, vascular dementia and mixed dementia.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Mar 2009

Trebunová Marianna, Slabá Eva, Habalová Viera, Gdovinová Zuzana

Abstract excerpt

In this work, we explored the existence of genetic variant within the apolipoprotein E gene transcriptional regulatory region. Upon a population study, three polymorphic sites (-491, -427 and -219) and two mutations were found. We investigated newly reported -427T/C promoter polymorphism in association with sporadic Alzheimer's disease (AD), vascular (VD) and mixed dementia (MD) along with APOE genotype and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Dementia

Share to Dementia, Vascular

Share to DNA Mutational Analysis

Share to Promoter Regions, Genetic

Share to Sex Factors

Source

Identifiers

PMID: 19142571
DOI: 10.1007/s00702-008-0178-5

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the -427T/C apolipoprotein E promoter polymorphism in the pathogenesis of Alzheimer's disease, vascular dementia and mixed dementia.PMID 19142571Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Association study of apolipoprotein E promoter polymorphism (-427 T/C) and Alzheimer's disease in a Tunisian population.Semantic proximity Read ↗

Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population.Semantic proximity Read ↗

The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms.Semantic proximity Read ↗

[A study on the relation between the apolipoprotein E promoter -427C/T polymorphism and Alzheimer's disease].Semantic proximity Read ↗

Association between Alzheimer disease and the -491T allele of regulatory region polymorphism of Apolipoprotein E in a Tunisian population.Semantic proximity Read ↗

Polymorphisms of the apolipoprotein E gene regulatory region and of the LDL receptor gene in late-onset Alzheimer's disease in relation to the plasma lipidic pattern.Semantic proximity Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.