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Article

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.

Molecular and cellular biology - 1 Sept 2006

Nieuwenhuis Erica, Motoyama Jun, Barnfield Paul C, Yoshikawa Yoshiaki, Zhang Xiaoyun, Mo Rong, Crackower Michael A, Hui Chi-Chung

Abstract excerpt

Hedgehog (Hh) signaling plays pivotal roles in tissue patterning and development in Drosophila melanogaster and vertebrates. The Patched1 (Ptc1) gene, encoding the Hh receptor, is mutated in nevoid basal cell carcinoma syndrome, a human genetic disorder associated with developmental abnormalities and increased incidences of basal cell carcinoma (BCC) and medulloblastoma (MB). Ptc1 mutations also occur in sporadic...

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Identifiers

PMID: 16914743
DOI: 10.1128/MCB.00295-06
PMCID: PMC1592833

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Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.PMID 16914743Read ↗

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Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

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