Article
Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.
Human molecular genetics - 1 Feb 1999
Smyth I, Narang M A, Evans T, Heimann C, Nakamura Y, Chenevix-Trench G, Pietsch T, Wicking C, Wainwright B J
Abstract excerpt
Mutations of the human Patched gene ( PTCH ) have been identified in individuals with the nevoid basal cell carcinoma syndrome (NBCCS) as well as in sporadic basal cell carcinomas and medulloblastomas. We have isolated a homologue of this tumour suppressor gene and localized it to the short arm o...
Topics
- Amino Acid Sequence
- Carcinoma, Basal Cell
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- DNA, Complementary
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Humans
- Medulloblastoma
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Patched Receptors