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Article

Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

Immunity - 1 Oct 1998

Hostert A, Garefalaki A, Mavria G, Tolaini M, Roderick K, Norton T, Mee P J, Tybulewicz V L, Coles M, Kioussis D

Abstract excerpt

CD4 and CD8 are crucial for the development and function of T cells. An intergenic deoxyribonuclease I hypersensitive site region (cluster CIII) directs expression in mature CD8 T cells only. Here, we show that two further independent regions from the CD8 gene locus in conjunction with cluster CIII restore transgene expression in appropriate immature thymocytes. Deletion of two of the intergenic cluster CIII...

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PMID: 9806636
DOI: 10.1016/s1074-7613(00)80633-0

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