Article
Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.
Immunity - 1 Oct 1998
Hostert A, Garefalaki A, Mavria G, Tolaini M, Roderick K, Norton T, Mee P J, Tybulewicz V L, Coles M, Kioussis D
Abstract excerpt
CD4 and CD8 are crucial for the development and function of T cells. An intergenic deoxyribonuclease I hypersensitive site region (cluster CIII) directs expression in mature CD8 T cells only. Here, we show that two further independent regions from the CD8 gene locus in conjunction with cluster CI...
Topics
- Alleles
- Animals
- CD8 Antigens
- Cell Differentiation
- Chromosome Mapping
- DNA
- Deoxyribonuclease I
- Female
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Male
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Mice, Transgenic