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Article

Induction of MHC class I expression by the MHC class II transactivator CIITA.

Immunity - 1 May 1997

Martin B K, Chin K C, Olsen J C, Skinner C A, Dey A, Ozato K, Ting J P

Abstract excerpt

Major histocompatibility complex (MHC) class I-deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site alpha DNA element is the target for CIITA-induced transactivation of class I. In addition, interferon-gamma (IFNgamma)-induced MHC class I expression...

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Source

Identifiers

PMID: 9175837
DOI: 10.1016/s1074-7613(00)80347-7

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Induction of MHC class I expression by the MHC class II transactivator CIITA.PMID 9175837Read ↗

Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA.Semantic proximity Read ↗

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expressionSemantic proximity Read ↗

The AIR-1 encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and .. more.Semantic proximity Read ↗

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction.Semantic proximity Read ↗

Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene.Semantic proximity Read ↗

Class II transactivator is required for maximal expression of HLA-DOB in B cells.Semantic proximity Read ↗

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.Semantic proximity Read ↗

Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levelsSemantic proximity Read ↗

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TNF-alpha suppresses IFN-gamma-induced MHC class II expression in HT1080 cells by destabilizing class II trans-activator mRNA.Semantic proximity Read ↗

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