Article
Induction of MHC class I expression by the MHC class II transactivator CIITA.
Immunity - 1 May 1997
Martin B K, Chin K C, Olsen J C, Skinner C A, Dey A, Ozato K, Ting J P
Abstract excerpt
Major histocompatibility complex (MHC) class I-deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site alpha DNA element is the target f...
Topics
- Breast Neoplasms
- Carcinoma
- Chloramphenicol O-Acetyltransferase
- Electrophoresis, Polyacrylamide Gel
- Gene Expression Regulation, Neoplastic
- Genes, MHC Class II
- Genes, Reporter
- Histocompatibility Antigens Class I
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Trans-Activators
- Transcriptional Activation
- Tumor Cells, Cultured