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Article

Development of all CD4 T lineages requires nuclear factor TOX.

The Journal of experimental medicine - 21 Jan 2008

Aliahmad Parinaz, Kaye Jonathan

Abstract excerpt

CD8(+) cytotoxic and CD4(+) helper/inducer T cells develop from common thymocyte precursors that express both CD4 and CD8 molecules. Upon T cell receptor signaling, these cells initiate a differentiation program that includes complex changes in CD4 and CD8 expression, allowing identification of transitional intermediates in this developmental pathway. Little is known about regulation of these early transitions or...

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Source

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Identifiers

PMID: 18195075
DOI: 10.1084/jem.20071944
PMCID: PMC2234360

Genes

TOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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