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Article

The CD8alpha gene locus is regulated by the Ikaros family of proteins.

Molecular cell - 1 Dec 2002

Harker Nicola, Naito Taku, Cortes Marta, Hostert Arnd, Hirschberg Sandra, Tolaini Mauro, Roderick Kathleen, Georgopoulos Katia, Kioussis Dimitris

Abstract excerpt

Ikaros family members are important regulatory factors in lymphocyte development. Here we show that Ikaros may play an important role in CD4 versus CD8 lineage commitment decisions by demonstrating: (1) that it binds to regulatory elements in the endogenous CD8alpha locus in vivo using thymocyte chromatin immunoprecipitations, (2) that Ikaros suppresses position effect variegation of transgenes driven by CD8...

Read the complete abstract on PubMed

Topics

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Share to CD8 Antigens
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ikaros Transcription Factor

Share to Lymph Nodes

Share to Lymphocytes

Share to Regulatory Sequences, Nucleic Acid

Share to Thymus Gland

Share to Zinc Fingers

Source

Identifiers

PMID: 12504015
DOI: 10.1016/s1097-2765(02)00711-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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